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Vitamin B12 (cobalamin) plays a key role in: Making healthy red blood cells (helping prevent certain types of anaemia) Supporting nerve function Helping normal energy metabolism Supporting cognitive function and mood (when deficiency is present) Because the body doesnt produce B12, we rely on dietary sources (primarily animal products and fortified foods) and on absorption through the gut

After a two-decade journey from its discovery, two approvals of siRNA therapeutics, ONPATTRO (patisiran) and GIVLAARI (givosiran), have been achieved by Alnylam Pharmaceuticals

Des-arg-BKN appears to be a prominent kinin in COVID-19

Furthermore, PDEVs possess a natural lipid bilayer structure that protects their payloadsuch as nucleic acids, proteins, and metabolitesfrom degradation while enhancing targeted delivery (Jin et al., 2024)